This one is something to keep an eye on, many moving parts here, TPP, Baloch separatist groups, a scenario in which the US does go for regime change in Iran and there is a power vacuum in Iran, Baloch separatist groups are also in Iran, with a power vacuum in Iran these groups can rise in power, this would apply more pressure to Pakistan and possibly open another front, and a stressed Pakistan is not something we should want, Plus there is China, China has a major trade route through there for their Belt and Road initiative the China-pakistan Economic Corridor (CPEC) is a concern, While the majority of it is not really something the TPP could realistically hit/target, there are a few spots that are close enough that it could concern China, China needs the stability or the perceived stability of CPEC, it's not something they are just going to let go of also part of that is Gwadar port.